It is the molecular environment that will bode tidings of peace or of war. Having yet to fall into that fateful encounter with the protein of their destiny, they have yet to even decide whether that protein is friend or foe. We call these cells “naive” not to mock their credulity and lack of sophistication, but simply to indicate that because of their inexperience they have remained undecided and noncommittal about the courses their lives will ultimately take. The investigators took “naive” T cells from mice that had been genetically engineered to react to egg white protein, and then incubated the cells with that very protein and with different doses of the activated vitamins. These bad boys protect against infection, but they also appear to play a role in multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease. Th17 cells are helper T cells that produce a number of inflammatory chemicals, including interleukin-17. Vitamins A and D Synergistically Suppress the Development of Th17 Cells To address this issue, the investigators examined the effects of these vitamins on the development of Th17 cells and in a mouse model of contact hypersensitivity. If so, using the activated forms of both vitamins together might allow clinicians to treat these disorders using doses low enough to avoid the nasty side effects. The investigators thus sought to see if the activated hormone form of vitamin A, retinoic acid, might also prove useful in battling autoimmune disorders. One hardly wants to cure, say, psoriasis if it means having to pass kidney stones. A number of studies suggest that the activated hormone form of vitamin D, calcitriol, has great promise for preventing and treating autoimmune diseases, but its usefulness in the clinical setting is currently limited because it promotes excessive accumulation of calcium in the blood and soft tissues. A new Japanese study published last July in the journal Immunology Letters ( 1) provides further evidence of this synergy, this time suggesting the dynamic duo can courageously combat the most flagellant of our inner impulses, keeping our wayward neutrophils in check and barring them from wandering too far down the winding road that leads to autoimmunity. One of the perennial topics of this blog is the synergy between vitamins A and D. Nourishing Traditional Diets with Sally Fallon Morell.Other Ingredients: Certified Organic Vegetable Tablet Coating (Pullulan). John’s Flower Essence*, Chamomile Flower Essence*, Rose Flower Essence*, Saffron Flower Essence*, Cardamom Seed Essence*, Chrysanthemum Flower Essence*, Honeysuckle Flower Essence*, Rosemary Leaf Essence*, Clove Bud Essence*, Sage Leaf Essence*. SuperPure® Herbal Extracts: Chaste Tree Berry Extract*, Shatavari Root Extract*, Rhodiola Root Extract*, Eleuthero Root Extract*, Licorice Root Extract*, Hawthorn Berry Extract*, Bioflavonoids, Motherwort Aerial Extract*, Sacred Lotus Seed Extract*, Astragalus Root Extract*, Holy Basil Leaf Extract*, Turmeric Rhizome Extract*, Organic Acacia*, Triphala Fruit Extract*, Pippali Fruit Extract*, Tangerine Peel Extract*, Black Pepper Fruit Extract*, Bacopa (Brahmi) Leaf Extract*, Gotu Kola Aerial Extract*, Barley Grass*, Fennel Seed Essence*, Calendula Flower Essence*, Lavender Flower Essence*, Passion Flower Essence*, St. Whole-Food Vitamins & Minerals: Vitamin A** (as beta-carotene with full spectrum carotenoids), Vitamin C**, Vitamin D3**, Vitamin E** (with full spectrum tocopherols and tocotrienols), Vitamin K1*, Vitamin K2, Thiamin (B1)**, Riboflavin (B2)**, Niacinamide (B3)**, Vitamin B6**, Folate*, Vitamin B12*, Biotin*, Pantothenic Acid**, Calcium, Iodine**, Magnesium, Zinc**, Selenium*, Copper**, Manganese**, Chromium (GTF)*, Molybdenum*, Choline, Inositol, PABA.
0 Comments
Leave a Reply. |